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Gonorrhea , colloquially known as the clap , is a sexually transmitted infection STI caused by the bacterium Neisseria gonorrhoeae. Gonorrhea is spread through sexual contact with an infected person. Gonorrhea can be prevented with the use of condoms , having sex with only one person who is uninfected, and by not having sex. Gonorrhea affects about 0. Gonorrhea infections of mucosal membranes can cause swelling, itching, pain, and the formation of pus.
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Antibodies against the Human papillomavirus 16 HPV16 E6 oncoprotein appear years prior to clinical diagnosis of anal and oropharyngeal cancer, but whether they develop around the time of HPV infection is unclear. This suggests E6 seroconversion may not occur around the time of oral, anal, or genital HPV16 acquisition. Recent reports found that seropositivity against the HPV16 E6 oncoprotein has a high sensitivity and specificity for HPVdriven oropharyngeal and anal cancer [2] , [3] , [4] and is often detected in pre-diagnostic serum among individuals with these cancers [5] , [6]. These analyses suggest that while HPV16 E6 seropositivity may not be commonly present prior to cervical or penile cancer [6] , it is often induced within five years prior to anal cancer [6] and ten or more years prior to oropharyngeal cancer [5]. Despite the detection of these antibodies years prior to anal and oropharyngeal cancer, it is unclear at what point during the natural history of HPV16, E6 seropositivity is induced by infection at these different anatomic sites.
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